Figure 3.

H4K16 was hypoacetylated throughout HML and at HMR. ChIP-seq of sonicated sheared chromatin against H4K16-acetyl from the left telomere of Chromosome III through HML (A) and 20 kb centered around HMR (B). (A) HML from the E to the I silencer (chromosomal coordinates 11,146–14,849) is shown as a shaded pink box. (B) HMR from the E to the I silencers (chromosomal coordinates 292,388–295,034) is shown as a shaded pink box. The X-axis represents chromosomal position in 5-kb increments. The distribution of sequence reads for the immunoprecipitate for each sample is shown in black, and the sequence reads from the input chromatin for that sample are in gray.