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. 2014 Feb 14;8:44. doi: 10.3389/fncel.2014.00044

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Copyright © 2014 Pedroni, Minh, Mallamaci and Cherubini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network-driven GDPs were reduced in frequency by DNQX and blocked by DNQX plus bicuculline. (A) Whole-cell recording of a P2 GC with biocytin revealed a cluster of several dye-coupled neurons. (B) Sample traces of spontaneous activity (GDPs) recorded from the same neuron in control conditions, in DNQX (20 μM), in DNQX and bicuculline (20 μM) and after wash. In the presence of DNQX, GDPs occurred at lower frequency. In DNQX it is visible also a plateau potential. (C) The GDP marked with an asterisk in the control trace is shown on an expanded time scale. (D) Voltage responses to depolarizing and hyperpolarizing currents steps of increasing intensity obtained from the same neuron. Note sodium and low threshold calcium spikes.