Table 3. Impact of alcohol consumption on the risk of female breast cancer, by ALDH2/ADH1B genotype.
| Cases /Controls |
OR-1a
(95% CI) |
OR-2b
(95% CI) |
|
| All | |||
| Never-drinker | 286/563 | 1 (ref.) | 1 (ref.) |
| Former drinker | 8/15 | 1.03 (0.43–2.47) | 1.17 (0.48–2.83) |
| Light drinker | 73/157 | 0.9 (0.66–1.23) | 0.92 (0.67–1.26) |
| Moderate drinker | 50/103 | 0.93 (0.64–1.35) | 0.95 (0.65–1.39) |
| Heavy drinker | 36/59 | 1.17 (0.76–1.82) | 1.33 (0.84–2.11) |
| Unknown | 3/15 | ||
| Ptrendc | 0.981 | 0.72 | |
| ADH1B (*2:rapid/*2:rapid) | |||
| Never-drinker | 165/337 | 1 (ref.) | 1 (ref.) |
| Former drinker | 6/9 | 1.36 (0.48–3.89) | 1.78 (0.59–5.34) |
| Light drinker | 40/90 | 0.91 (0.6–1.38) | 0.93 (0.61–1.43) |
| Moderate drinker | 31/65 | 0.97 (0.61–1.55) | 1.06 (0.66–1.72) |
| Heavy drinker | 20/33 | 1.24 (0.69–2.22) | 1.61 (0.85–3.02) |
| Unknown | 3/5 | ||
| Ptrendc | 0.829 | 0.418 | |
| ADH1B (*1:slow/*2:rapid) | |||
| Never-drinker | 104/200 | 1 (ref.) | 1 (ref.) |
| Former drinker | 2/4 | 0.97 (0.17–5.39) | 0.91 (0.16–5.11) |
| Light drinker | 26/56 | 0.88 (0.52–1.49) | 0.85 (0.5–1.45) |
| Moderate drinker | 17/33 | 0.97 (0.51–1.85) | 0.88 (0.45–1.71) |
| Heavy drinker | 13/21 | 1.17 (0.56–2.45) | 1.12 (0.52–2.4) |
| Unknown | 0/8 | ||
| Ptrendc | 0.956 | 0.832 | |
| ADH1B (*1:slow/*1:slow) | |||
| Never-drinker | 15/23 | 1 (ref.) | 1 (ref.) |
| Former drinker | 0/2 | NA NA | NA NA |
| Light drinker | 5/10 | 0.73 (0.2–2.6) | 0.82 (0.21–3.25) |
| Moderate drinker | 2/5 | 0.65 (0.11–3.92) | 0.59 (0.09–3.93) |
| Heavy drinker | 3/5 | 1 (0.2–4.92) | 1.7 (0.16–17.69) |
| Unknown | 0/2 | ||
| Ptrendc | 0.764 | 0.887 | |
| ALDH2 (*1:active/*1:active) | |||
| Never-drinker | 99/196 | 1 (ref.) | 1 (ref.) |
| Former drinker | 5/11 | 0.91 (0.31–2.7) | 1.03 (0.34–3.16) |
| Light drinker | 47/108 | 0.86 (0.56–1.32) | 0.88 (0.57–1.36) |
| Moderate drinker | 37/75 | 0.99 (0.62–1.58) | 0.98 (0.61–1.59) |
| Heavy drinker | 31/53 | 1.17 (0.7–1.95) | 1.21 (0.7–2.11) |
| Unknown | 3/12 | ||
| Ptrendc | 0.801 | 0.887 | |
| ALDH2 (*1:active/*2:null) | |||
| Never-drinker | 149/273 | 1 (ref.) | 1 (ref.) |
| Former drinker | 3/4 | 1.34 (0.29–6.11) | 1.94 (0.4–9.27) |
| Light drinker | 26/49 | 0.93 (0.55–1.57) | 0.97 (0.57–1.67) |
| Moderate drinker | 13/27 | 0.82 (0.4–1.66) | 0.85 (0.41–1.76) |
| Heavy drinker | 5/6 | 1.51 (0.45–5.07) | 1.82 (0.52–6.36) |
| Unknown | 0/3 | ||
| Ptrendc | 0.871 | 0.892 | |
| ALDH2 (*2:null/*2:null) | |||
| Never-drinker | 38/92 | 1 (ref.) | 1 (ref.) |
| Former drinker | 0/0 | NA NA | NA NA |
| Light drinker | 0/0 | NA NA | NA NA |
| Moderate drinker | 0/1 | NA NA | NA NA |
| Heavy drinker | 0/0 | ||
| Unknown | 0/0 | ||
| Ptrendc | NA | NA | |
aLogistic regression model controlling for matching factors only.
bLogistic regression model controlling for matching factors plus alcohol consumption, smoking status, body-mass index, regular exercise, family history of breast cancer, age at menarche, parity, hormone-replacement therapy, and mode of referral to hospital.
cTrends for genotypes were assessed by a test that used scores for drinking status (0, Never-drinker; 1, Former drinker; 2, Light drinker; 3, Moderate drinker and 4, Heavy drinker).