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. 2014 Jan 15;7:9. doi: 10.1186/1756-8722-7-9

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Copyright © 2014 Han et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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BENC-511 activates apoptotic signaling in MM cells. (A) Myeloma cells (RPMI-8226, JJN3, OCI-MY5, U266, LP1) were treated with 4 μM BENC-511 or DMSO for 24 hours followed by the analysis of the expression of PARP, Caspase-3, and GAPDH. (B) OPM2, RPMI-8226 and LP1 cells were treated with increasing concentrations of BENC-511 for 24 hours. (C) OPM2 and RPMI-8226 were incubated with 4 μM of BENC-511 for the indicated time. After incubation, cells were harvested and total proteins were isolated. Cell lysates were applied for PARP and GAPDH analyses.