Table 2.
Toxicology of BENC-511 in nude mice: biochemical analysis
| Treatment | ALT, U/L | AST, U/L | BUN, mmol/L | Cr, μmol/L |
|---|---|---|---|---|
| Control |
62 (29.3 to 94.7) |
237.7 (214.1 to 261.2) |
10.3 (9.0 to 11.5) |
10.7 (7.9 to 13.5) |
| BENC-511 |
48.2 (35.3 to 61.1) |
189 (170.8 to 207.2) |
11.3 (8.9 to 13.7) |
12.4 (11.2 to 13.6) |
| P | 0.6 | 0.3 | 0.3 | 0.4 |
Data represent mean ± SD of 6 nude in each group after treatment with BENC-511 at 50 mg/kg body weight or vehicle for 20 days. At the completion of the experiment, mice were sacrificed and their sera were prepared for chemistry analysis. Data represent mean values and 95% confidence intervals. ALT = Alanine transaminase; AST = Aspartate aminotransferase; BUN = Blood urea nitrogen; Cr = Creatinine.