Table 1.

Comparison of mitochondrial area in myelinated and unmyelinated fibers of saphenous nerves obtained from naive wild type (WT) and σ ₁ -receptor knockout (σ ₁ R-KO) mice and from animals of both genotypes 10 days after treatment with paclitaxel or its vehicle

		Mean mitocondrial area (μm 2 )
Genotype	Treatment	Myelinated	Unmyelinated
WT	Naive	0.102 ± 0.002	0.135 ± 0.016#
	Vehicle	0.117 ± 0.008	0.164 ± 0.006##
	Paclitaxel	0.134 ± 0.007**	0.161 ± 0.009#
σ 1 R-KO	Naive	0.107 ± 0.005	0.134 ± 0.010#
	Vehicle	0.116 ± 0.005	0.164 ± 0.021##
	Paclitaxel	0.115 ± 0.006	0.170 ± 0.007##

Values represent the mean mitochondrial area of the results obtained in 3–5 animals per experimental group. Statistically significant differences in comparison to naive WT animals: ^**P < 0.01 (one way ANOVA followed by Bonferroni test). Note that paclitaxel did not significantly enhance the mean mitochondrial area in σ₁R-KO mice myelinated fibers, nor in any genotype in unmyelinated fibers. Statistically significant differences in comparison to myelinated fiber: ^#P < 0.05; ^##P < 0.01 (two way ANOVA followed by Bonferroni test). Note that mitochondrial area was greater in unmyelinated than myelinated fibers in all the experimental groups.