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Central administration of recombinant CTRP4 alters hypothalamic orexigenic neuropeptide expression. Shown is the quantitative real-time PCR analysis of Npy (A), Agrp (B), and Mc4r (C) expression in the hypothalamus of chow- or HFD-fed mice (n = 6 mice/group) injected centrally with vehicle control or recombinant CTRP4. Hypothalami were harvested 3 h post-injection. *, p < 0.05.
