FIGURE 1.

Anthrax LT treatment causes a reduction in lactate accumulation. A, levels of serum lactate in untreated mice (control, n = 13) or mice treated with LT for 24 h (n = 9) and 48 h (n = 7). B, levels of lactate in the supernatants collected from HepG2 cells (5 × 10³) cultured under normoxic or hypoxic conditions for 24 h in the presence (LT) or absence (M) of LT. C, uptake of glucose by HepG2 cells (5 × 10³) pretreated with (LT) or without (M) LT for 3 h, and then subsequently cultured in normoxic or hypoxic conditions for 24 h. Error bars shown in A–C denote standard deviation generated from three independent experiments. *, statistical analysis was performed using the two-tailed Student's t test.