FIGURE 7.

Regulation of hepatic ARV1 RNA levels in the mouse. A, DGAT1; B, CD36 expression in AdhARV1-injected mouse livers compared with AdNull control. C, male A129/SvEv strain mice were provided overnight (12 h) with low fat rodent diet supplemented with various nuclear hormone receptor agonists as follows: RXR, 30 mg/kg LG268; PPARα, 0.5% fenofibrate; PPARγ, 150 mg/kg troglitazone; PXR, 0.05% pregnenolone α-carbonitrile; CAR, 3 mg/kg TCPOBOP; FXR, 0.5% chenodeoxycholic acid; LXR, 50 mg/kg T0901317; LXR + RXR, 30 mg/kg LG268 + 50 mg/kg T0901317, or vehicle (0.9% carboxymethylcellulose, 9% PEG, 0.05% Tween), n = 4 per group. Male A129 wild type (Pparα^+/+) and Pparα^−/− mice were provided diets with and without 0.5% fenofibrate (D) for 7 days, n = 4/group, or 5 mg/kg GW7647 or vehicle twice by oral gavage over 14 h, n = 5 per group. RNA levels were measured by quantitative RT-PCR using cyclophilin as the invariant housekeeping gene. Values depict mean ± S.E. Results were analyzed by one-way unfolded protein response using (A–C) Dunnett's post hoc comparison., *, p < 0.05; ***, p < 0.001 versus control group. D and E, Neuman-Keul's post hoc comparison, groups with different letters are significantly different at p < 0.05.