TABLE 1.
Mammalian orthologs of yeast genes required for liporesistance, previously associated with glucose homeostasis, insulin secretion, dyslipidemia or oxidative stress
Associations determined through the National Center for Biotechnology (NCBI) database National Human Genome Research Institute catalog of published genome-wide association studies (genome.gov) and HuGE Navigator human genome database.
| Yeast gene | Human ortholog | Associated metabolic syndrome |
|---|---|---|
| GET3 | ASNA1 (46.5%) | ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. (PMID 17289575) |
| PCP1 | PARL (32.3%) | L262V polymorphism of PARL is associated with earlier onset of T2D. (PMID 19185381) |
| MCK1 | GSK3β (43.5%) | Mice with β-cell overexpression of GSK3β have reduced β-cell mass and proliferation. (PMID 18219478) |
| ARV1 | ARV1 | Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. (PMID 20663892) |
| GCN5 | GCN5 (46%) | GCN5-mediated transcriptional control of the metabolic coactivator PGC1β through lysine acetylation. (PMID 19491097) |
| FPS1 | AQP9 (28%) | Gene expression of paired abdominal adipose AQP7 and liver AQP9 occurring in patients with morbid obesity and relationship with glucose abnormalities. (PMID 19615702) |
| IFM1 | MTIF2 (36%) | Genetic association analysis of 13 nucleus-encoded mitochondrial candidate genes with type II diabetes mellitus, the DAMAGE study. (PMID 19209188) |
| ITR1 | GLUT2 (27%) | GLUT2 was thus demonstrated to be required for maintaining normal glucose homeostasis and normal function and development of the endocrine pancreas. (PMID 9354799) |
| MDJ1 | DNAJB9 (46%) | MDG1/ERdj4 an ER-resident DnaJ family member suppresses cell death induced by ER stress. (PMID 12581160) |
| FEN1 | ELOVL6 (30.6%) | ELOVL6 genetic variation is related to insulin sensitivity. (PMID 21701577) |
| MGR2 | ROMO1 (43%) | Serum deprivation-induced reactive oxygen species production is mediated by Romo1. (PMID 19904609) |
| ETR1 | MECR (36.4%) | Structural enzymological studies are of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway, and new insights into its substrate recognition properties are given. (PMID 18479707) |