TABLE 5.
Genes with altered expression in AdhARV1-treated mice
Up-regulated (fold change 1.5 or more p < 0.001) and down-regulated (fold change 0.5 or less, p < 0.001) genes in livers with hARV1 overexpression. Results were calculated based on data of six sets of Affymetrix oligonucleotide arrays. Genes were categorized by GO process and ranked within these groups by fold change.
| Process | Gene | -Fold change |
|---|---|---|
| Lipid metabolism | DGAT1 | 1.6 |
| DNA replication and repair | POLE2 | 2.2 |
| MCM4 | 2.2 | |
| UNG | 2.2 | |
| NASP | 1.7 | |
| Protein phosphorylation | BUB1 | 2.6 |
| PBK | 1.8 | |
| PLK4 | 1.6 | |
| BRD4 | 1.8 | |
| STK25 | 0.391 | |
| RNA transport | NUP35 | 1.8 |
| FMR1 | 1.7 | |
| Chromatin modification | ASF1B | 2.7 |
| KDM2B | 1.7 | |
| Miscellaneous | DET1 | 9.9 |
| COX6B2 | 4.6 | |
| GPR98 | 3.3 | |
| GSTM3 | 2.3 | |
| MMP14 | 2.2 | |
| SULT1C1 | 2.2 | |
| ITIH5 | 2.1 | |
| DCAKD | 1.8 | |
| NT5DC2 | 1.6 | |
| ABHD10 | 1.6 | |
| PPM1D | 1.5 | |
| EIFAD | 1.5 | |
| ZFP871 | 0.486 | |
| CAR5 | 0.412 | |
| TTC39C | 0.409 | |
| LCN13 | 0.369 | |
| Uncharacterized | 4933439C10Rik | 6.2 |
| EST X83313 | 5.7 | |
| RIKEN cDNA 1810010H24 | 0.479 | |
| RIKEN cDNA 5730414N17 | 0.441 | |
| AW549877 | 0.422 |