Figure 4.

Load-driven reduction in the activity levels of collagenases, gelatinases, and MMP13, as well as the phosphorylation levels of p38 MAPK and NFκB in normal mice. (A) Reduction of collagenase activity in response to knee loading at 0.5, 1, and 3 N. The dotted line indicates the activity level of the sham loaded control without application of knee loading. (B) Reduction in gelatinase activity in response to knee loading at 0.5, 1, and 3 N. (C) Reduction in MMP13 activity in response to knee loading at 0.5 and 1 N. (D) Reduced phosphorylation levels of p38 MAPK (p-p38) and NFκB (p- NFκB) in response to knee loading at 0.5 and 1 N. n = 3 per group (A-D).