Table 2.
Modular enrichment analysis
| Gene module | Module correlation to EtOH consumption | P value of correlation to consumption | Differentially expressed (DE) genes in module | Module size | P value of enrichment in DE genes | Functional category enrichment | Cell type-specific enrichment |
|---|---|---|---|---|---|---|---|
|
Red |
0.63 |
1.08E-04 |
74 |
307 |
5.02E-16 |
Vesicle-mediated transport, Endocytosis |
Oligodendrocytes |
|
Brown |
0.55 |
1.23E-03 |
88 |
846 |
6.72E-02 |
Transport, Synaptic transmission, Toll-like receptor & chemokine signaling |
Neurons, Astrocytes |
|
Pink |
0.47 |
6.28E-03 |
30 |
150 |
1.89E-05 |
Cellular component organization or biogenesis, endosomal transport |
- |
|
Blue |
0.35 |
4.77E-02 |
104 |
936 |
9.16E-03 |
Synaptic transmission, Neurotransmitter secretion |
Neurons, Astrocytes, Oligodendrocytes |
| Black |
0.13 |
0.47 |
1 |
306 |
1 |
Regulation of developmental process, Neurogenesis |
Astrocytes, Neurons, Oligodendrocytes |
| Grey |
0.04 |
0.85 |
15 |
3339 |
1 |
- |
Neurons, Oligodendrocytes |
| Magenta |
-0.08 |
0.65 |
0 |
130 |
1 |
Blood vessel development, Angiogenesis, BMP signaling |
Astrocytes, Microglia |
| Green |
-0.40 |
2.44E-02 |
10 |
445 |
1 |
Oxidative phosphorylation, Ribosome biogenesis |
Astrocytes |
|
Turquoise |
-0.63 |
1.08E-04 |
224 |
1125 |
9.85E-36 |
Synaptic transmission, Chemokine signaling, Toll-like receptor signaling |
Neurons, Astrocytes |
| Yellow | -0.74 | 1.35E-06 | 196 | 719 | 1.90E-52 | Electron transport chain, Translation, Ribosome biogenesis | - |
Enrichment for differentially expressed genes, functional categories, and cell type-specific markers in coexpressed gene modules detected by WGCNA. Relevant modules are highlighted in bold fonts.