Figure 3.

Brain volume change, expressed as percentage of the intracranial volume, is a function of mean daily intake for all monkeys following 6 months of drinking (solid symbols and lines) and following 12 months of drinking (open symbols/dashed lines). (a) Volume change of the allocortex is negatively correlated with mean daily intake following both 6 and 12 months of 22 h free access to 4% ethanol. (b) Volume change of the hippocampus is negatively correlated with mean daily intake following 6 months of drinking but the relationship between hippocampal volume change and drinking is not significant at 12 months. (c) Positive correlation between volumetric change in lateral ventricles and mean daily intake is statistically significant at 12 months but not 6 months.