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. 2013 Oct 30;39(4):841–854. doi: 10.1038/npp.2013.284

Figure 2.

Figure 2

Efficacy of 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMGR) inhibition by simvastatin and effects on neuronal and astrocytic content in different brain regions. (a) Representative western blot and densitometric analysis of nSREBP-2 in amygdala (Am), hippocampus (Hp), prefrontal cortex, dorsal striatum, and ventral striatum. (b) Representative western blot and densitometric analysis of low-density lipoprotein receptor (LDLr) in amygdala (Am), hippocampus (Hp), prefrontal cortex, dorsal striatum, and ventral striatum. (c) Representative western blot and densitometric analysis of the neuronal marker NeuN in amygdala (Am), hippocampus (Hp), prefrontal cortex, dorsal striatum, and ventral striatum. (d) Representative western blot and densitometric analysis of the astrocytic marker GFAP in amygdala (Am), hippocampus (Hp), prefrontal cortex, dorsal striatum, and ventral striatum. Protein levels were normalized with α-tubulin. The data are expressed as arbitrary units obtained by analyzing the protein bands with Image J software for Windows, for details see the main text. All the results obtained are presented as the mean±SD *P<0.05, **P<0.01; Student's t-test with respect to the control group of the same brain region analyzed. n=6 animals/group. Veh, vehicle-treated rats. Sim, simvastatin-treated rats.