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. 2013 Oct 30;39(4):841–854. doi: 10.1038/npp.2013.284

Figure 6.

Figure 6

p-CREB and PSD-95 distribution in hippocampus of simvastatin- and vehicle-treated rats. (a) Overview of p-CREB immunohistochemistry in a sagittal section of rat brain. Hippocampal formation showed higher positivity in the nucleus of pyramidal cells in CA1–CA3 fields and of granule cells in DG. Mossy cells in the hylus were especially immunoreactive. (b) Overview of PSD-95 immunohistochemistry in a sagittal section of rat brain showing immunopositivity localized to pyramidal cell layer of CA1–CA3, to granule neurons of DG, and to hylar mossy neurons. GL, granule cell layer; Hp, hippocampus; ML, molecular layer; Or, stratum oriens; PoDG, polymorphic layer; Pyr, stratum pyramidale; Rad, stratum radiatum.