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. 2013 Nov 13;39(4):919–933. doi: 10.1038/npp.2013.292

Figure 2.

Figure 2

WIN55,212-2 prevents the CMS-induced impairment in LTP in the vSub-NAc pathway. (a) When tested on day 23, the CMS-Veh and CMS-AM+WIN groups demonstrated significantly reduced amplitude compared with the No CMS-Veh and CMS-WIN groups post HFS (*p<0.05). (b) When tested on day 23, the CMS-Veh and CMS-AM+WIN groups demonstrated significantly reduced slope compared with the CMS-WIN group post HFS. Also the CMS-WIN+AM showed reduced slope compared with the No CMS-Veh group post HFS (*p<0.05). (c) When tested on day 28, all the groups demonstrated similar amplitude, suggesting intact LTP. (d) When tested on day 28, all the groups demonstrated similar slope, suggesting intact LTP. (e) Representative traces in the NAc taken before (continuous line) and 1 h after (broken line) HFS to the vSub (calibration: 0.2 mV, 10 msec).