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Biosynthesis of miRNAs and their role in pancreatic cancer. The RNA Pol II transcribes pri-miRNA, which is cleaved by DRO-SHA/DGCR8 complex to form pre-miRNA. Exportin-5 transports this pre-miRNA to the cytosol, where Dicer forms the mature single stranded miRNA. This strand then enters the RISC (RNA induced silencing complex) which suppresses the target mRNA either by translational repression (incomplete complementarity) or by target degradation (complete complemetarity).
