Table 1.

miRNAs as Potential Therapeutic Targets in Pancreatic Cancer

miRNA	Tumor suppressor/oncogenic	Predicted target genes	Cellular processes affected	References
miR 21	Oncogenic	CDK6, PDCD4, CDKN1A, FAS, IL6R, SOCS5, APAF1, NFlB, TPM1	Apoptosis, cellular proliferation, migratory and invasive properties	[91]
miR-221	Oncogenic	CDKN1B, CDKN1C, KIT	Cell migration and proliferation	[90]
miR-155	Oncogenic	AGTR1, APC, ARID2, BACH1, CEBPB, CYR61, DET1, EDN1, ETS1, FADD, FGF7, FOXO3	Cell migration	[87]
miR-196a	Oncogenic	NRAS, HOXB8, HMGA2, ANNEXIN A1	Cell proliferation and differentiation	[102]
Let 7	Tumor suppressor	LIN28, HRAS, KRAS, HMGA2, TRIM71, NF2	Cellular proliferation	[61]
miR-34a	Tumor suppressor	NOTCH1, BCL2, E2F3, VEGFA, SIRT1, CCND1, CDK6	Apoptosis, cellular proliferation	[100]
miR-217	Tumor suppressor	KRAS, SIRT1, PTEN	Proliferation, survival and invasion	[103]
miR-216a	Tumor suppressor	PTEN, CDC42, CD44, SIRT1	Tumorigenecity	[104, 105]