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. 2014 Jan;16(1):73–83. doi: 10.1593/neo.131510

Figure 3.

Figure 3

Inflammatory signaling pathway according to animal groups. (A) Gastrin administration in APCMin/+ mice (group 2) significantly increased the expression of CD31, whereas the expression of CD31 was significantly decreased in groups 3 and 4 (P < .005). (B) The phosphorylation levels of p38, JNK, and ERK were determined by Western blot analysis. The phosphorylation of MAPKs was significantly inhibited in groups 3 and 4. (C) Changes in TNF-α mRNA expression and serum protein levels. The treatment with PPI inhibited the levels of TNF-α induced by gastrin in groups 3 and 4. (D–E) The expression of COX-2 and the level of PGE2 were investigated by Western blot analysis and ELISA, respectively. Group 2 showed the induction of COX-2 and PGE2; however, PPI administration decreased the levels of indicated factors in groups 3 and 4.