Table 1.
Demographics and Clinical characteristics [means ± standard deviation or proportions (n)] at DCCT closeout stratified by quartile of oxLDL in LDL-IC (n = 465 with Year 12 ICA IMT).
| oxLDL in LDL-IC Quartiles (cut-points, mg/L) | |||||
|---|---|---|---|---|---|
| 1st Quartile (0.37-34.1) | 2nd Quartile (34.5-70.4) | 3rd Quartile (70.5-125.9) | 4th Quartile (126-1182) | Trend P | |
| Age (yrs) | 33 ± 6.4 | 34 ± 7.2 | 35 ± 6.6 | 35 ± 6.7 | 0.009 |
| Male | 42% (50) | 52% (63) | 51% (57) | 63% (72) | 0.003 |
| DCCT Intensive Treatment | 43% (51) | 56% (68) | 50% (55) | 36% (41) | 0.179 |
| Primary Retinopathy Cohort | 45% (54) | 48% (59) | 50% (55) | 37% (43) | 0.269 |
| Duration of T1DM (yrs) | 12 ± 5.0 | 12 ± 5.0 | 13 ± 5.3 | 13 ± 4.9 | 0.081 |
| AER (mg/24 hours)† | 9.3 ± 2.4 | 12.2 ± 2.8 | 11.8 ± 3.0 | 17.1 ± 4.5 | <0.001 |
| HbA1c (%) | 8.2 ± 1.4 | 8.3 ± 1.7 | 8.4 ± 1.8 | 8.8 ± 1.7 | 0.027 |
| LDL-Cholesterol (mg/dL) | 99 ± 24 | 113 ± 28 | 115 ± 29 | 125 ± 32 | <0.001 |
| HDL-Cholesterol (mg/dL) | 55 ± 14 | 51 ± 12 | 50 ± 11 | 49 ± 12 | <0.001 |
| LDL-Particle Concentration (nmol/L) | 912 ± 353 | 1029 ± 405 | 1051 ± 385 | 1158 ± 384 | <0.001 |
| HDL-Particle Concentration (ìmol/L) | 36 ± 7 | 35 ± 7 | 35 ± 6 | 33 ± 6 | <0.001 |
| Systolic BP (mmHg) | 113 ± 11 | 116 ± 10 | 117 ± 13 | 119 ± 11 | <0.001 |
| Diastolic BP (mmHg) | 72 ± 7.8 | 73 ± 8.6 | 76 ± 8.5 | 77 ± 7.9 | <0.001 |
| Current Smoker | 18% (21) | 24% (29) | 22% (24) | 13% (15) | 0.327 |
AER, albumin excretion rate;
*
Unadjusted;
†
Due to non-normal distributions geometric means are presented.