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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Trends Pharmacol Sci. 2013 Apr 1;34(5):290–298. doi: 10.1016/j.tips.2013.02.006

Figure 1.

Figure 1

Structural representations of Gαq and Gβγ with potential sites for small molecule interactions. (a) Gαq bound to YM-254890. The α helical domain is in blue, the Ras-like domain is in red and the linkers connecting the two domains are in green. GDP is in CPK and YM-254890 is in space fill yellow. Rendered from PDB 3AH8. (b) Surface representation of Gβ. In red is the contact surface for the SIGK peptide used in a completion screen for small molecule discovery. Rendered from PDB 1XHM using MolSoft ICM.