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. 2014 Feb 14;5:15. doi: 10.3389/fpsyt.2014.00015

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Copyright © 2014 Lee, Dvorak and Fenton.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ethosuximide attenuated the cognitive control impairment of NVHL rats. (A) In the untreated group, the NVHL rats were slower to learn the two-frame task and showed an impairment when compared to the control rats (learning curve: two-way repeated-measures ANOVA group: F_1,64 = 53.84, p < 0.0001; trial: F_7,64 = 8.80, p < 0.0001; interaction: F_7,64 = 1.79, p = 0.10); inset: total number of entrances: t₈ = 4.69, p = 0.002). (B) Ethosuximide treatment attenuated the learning impairment in the NVHL rats when compared to control rats (learning curve: two-way repeated-measures ANOVA group: F_1,64 = 5.86, p = 0.02; trial: F_7,64 = 9.79, p < 0.0001; interaction: F_7,64 = 2.40, p = 0.03); inset: total number of entrances: t₈ = 1.87, p = 0.10). (C) Olanzapine treatment did not improve performance of the NVHL rats on the two-frame task (learning curve: two-way repeated-measures ANOVA group: F_1,64 = 42.87, p < 0.0001; trial: F_7,64 = 9.66, p < 0.0001; interaction: F_7,64 = 0.19, p = 0.99); inset: total number of entrances: t₈ = 3.10, p = 0.02).