Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Formation of the class Ia RNR diferric-tyrosyl radical cofactor. (a) Formation reaction for the diferric-tyrosyl radical cofactor. (b) Model for the biosynthesis pathway of active Rnr2. Tah18 and Dre2 are proposed to donate electrons for diferric-tyrosyl radical formation on Rnr2. The [2Fe-2S] Grx3/4 homodimer most likely donates iron for the cofactor. Reducing equivalents from Dre2 may also be required for iron delivery (dashed line).
