Figure 2.

Immunohistochemistry for EpCAM and von Willebrand Factor (vWF) in serial sections of liver biopsies of Primary Biliary Cirrhosis (PBC) and HCV-related cirrhosis (HCV-C) patients. (A,B) In PBC, EpCAM+ ductular reaction (DR: yellow arrow) are in strict relationship with vWF+ vessels (red arrows); reactive ductules are present at the interface with cirrhotic nodule, and are strictly associated with EpCAM+ Hepatocytes (newly derived from HPCs); (C,D) In HCV-C samples, vessels (red arrows) are mostly located within fibrous septa and are not in relationship with reactive ductules (yellow arrows). Original magnification 40× (A-D)