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. 2014 Jan 24;15:66. doi: 10.1186/1471-2164-15-66

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Copyright © 2014 Cardoso et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Citric acid pathway (KEGG database). Enzymes are identified by E.C. number and those corresponding to differentially expressed genes are highlighted according to the color scale. Color codes for each gene at T0 are as follows: red for up-regulated, green for down-regulated and grey for no differential expression. E.C number and correspondent enzyme: 1.1.1.37 - Malate dehydrogenase; 1.1.1.41 - Isocitrate dehydrogenase (NAD(+); 1.1.1.42 -Isocitrate dehydrogenase (NADP(+); 1.2.4.1 - Pyruvate dehydrogenase (acetyl-transferring) (Pyruvate dehydrogenase) 1.3.99.1 - Succinate dehydrogenase (Fumarate reductase); 2.3.3.1 - Citrate (Si)-synthase, 4.1.1.32 – Phosphopyruvate carboxylase; 4.2.1.2 – Fumarate hydratase (Fumarase).