Table 1.
Baseline characteristics of thrombolyzed patients from 2005 to 2011 in Joinville, Brazil
| 2005 (n = 7) | 2006 (n = 18) | 2007 (n = 22) | 2008 (n = 54) | 2009 (n = 31) | 2010 (n = 37) | 2011 (n = 51) | All (n = 220) | |
|---|---|---|---|---|---|---|---|---|
| Demographic data | ||||||||
| Mean age ± SD, years | 65 ± 10.7 | 69.8 ± 13.8 | 63 ± 14.0 | 63.6 ± 12.5 | 68.5 ± 15.1 | 71.2 ± 13.1 | 65.1 ± 14.7 | 66.6 ± 2.9 |
| Females, % | 71.4 | 66.6 | 36.3 | 47.5 | 41.4 | 44.7 | 45.1 | 50.4 |
| Age >80 years, % | 0 | 22.2 | 4.5 | 1.9 | 17.3 | 40.5 | 15.7 | 14.6 |
| Years of education | ||||||||
| <4 years (illiterate) | 1 (16.7) | − | 1 (4.5) | 18 (35.3) | 13 (42) | 11 (32.4) | 19 (38.8) | 63 (30.2) |
| 4 years | 5 (83.3) | 6 (35.3) | 10 (45.5) | 17 (33.3) | 11 (35) | 17 (50) | 19 (38.8) | 83 (39.9) |
| 8 years | − | 9 (52.3) | 9 (40.9) | 9 (17.6) | 5 (16.1) | 1 (2.9) | 3 (6.1) | 36 (17.3) |
| 11 years | − | 2 (11.8) | 2 (9.1) | 7 (13.7) | 1 (3.2) | 5 (14.7) | 8 (16.3) | 25 (12) |
| >11 years | − | − | − | − | 1 (3.2) | − | − | 1 (0.5) |
| Unknown | − | 1 | − | 3 | − | 3 | 2 | 12 |
| Premorbid risk factor | ||||||||
| Hypertension | 6 (85.7) | 14 (77.7) | 12 (54.5) | 46 (85.2) | 21 (72.4) | 28 (75.6) | 41 (80.3) | 168 (77) |
| Diabetes | 1 (14.3) | 5 (27.7) | 4 (18.2) | 21 (38.9) | 6 (20.7) | 11 (28.9) | 14 (27.5) | 62 (28.4) |
| Atrial fibrillation | 1 (14.3) | 4 (22.2) | 6 (27.3) | 18 (33.4) | 5 (17.2) | 0 | 10 (19.6) | 44 (20.2) |
| Smoker (current) | 2 (28.6) | 5 (27.7) | 5 (22.7) | 5 (12.8) | 3 (10.3) | 5 (13.5) | 10 (19.6) | 35 (16.1) |
| Dyslipidemia | 2 (28.6) | 3 (16.6) | 8 (36.3) | 4 (7.4) | 5 (17.3) | 25 (67.5) | 9 (18) | 56 (25.7) |
| Ischemic heart disease | 0 | 2 (11.1) | 2 (9.1) | 7 (12.9) | 2 (6.9) | 4 (10.8) | 3 (5.9) | 20 (9.2) |
| Clinical measures | ||||||||
| Admission NIHSS score | ||||||||
| 0 – 8 (mild) | 2 (28.6) | 1 (5.5) | 4 (18.2) | 7 (13.2) | 8 (28.6) | 6 (16.2) | 15 (28.3) | 43 (19.7) |
| 9 – 13 (moderate) | 1 (14.3) | 8 (44.4) | 7 (31.8) | 13 (24.5) | 3 (10.7) | 11 (29.7) | 21 (39.6) | 64 (29.4) |
| 14 – 22 (severe) | 4 (57.1) | 8 (44.4) | 9 (40.9) | 26 (49) | 3 (10.7) | 14 (37.8) | 16 (30.2) | 80 (36.7) |
| >22 (coma) | 0 | 1 (5.5) | 2 (9.1) | 7 (13) | 14 (50) | 6 (16.2) | 1 (1.8) | 31 (14.2) |
| Median (IQR) | 14 (11 – 18) | 15 (9 – 22) | 14 (8 – 17) | 15 (11 – 20) | 15 (9 – 20) | 14 (7 – 21) | 11 (9 – 15) | 14 (9 – 19) |
| Bamford classification | ||||||||
| LACS | 0 | 2 (11.1) | 2 (9.1) | 5 (9.3) | 3 (9.7) | 1 (2.7) | 3 (5.9) | 16 (7.3) |
| PACS | 1 (14.3) | 8 (44.4) | 8 (36.4) | 14 (25.9) | 14 (45.2) | 10 (27) | 35 (68.6) | 90 (40.9) |
| TACS | 6 (78.6) | 8 (44.4) | 11 (50) | 28 (51.9) | 12 (38.7) | 21 (56.8) | 11 (21.6) | 89 (40.5) |
| POCS | 0 | 0 | 1 (4.5) | 7 (13) | 2 (6.5) | 5 (13.6) | 2 (3.9) | 17 (7.7) |
| TOAST classification | ||||||||
| Lacunar | 0 | 2 (11.1) | 2 (9.1) | 2 (3.7) | 2 (6.5) | 3 (8.1) | 9 (17.6) | 20 (9.1) |
| Atherothrombotic | 3 (42.8) | 5 (27.7) | 5 (22.7) | 21 (38.9) | 5 (16.1) | 16 (43.2) | 13 (25.5) | 68 (30.9) |
| Cardioembolic | 3 (42.8) | 6 (33.3) | 7 (31.8) | 17 (31.5) | 11 (35.5) | 10 (27) | 20 (39.2) | 67 (30.5) |
| Undetermined | 1 (14.3) | 4 (22.2) | 7 (31.8) | 14 (26) | 16 (52) | 7 (18.9) | 3 (5.9) | 52 (23.6) |
| Other | 0 | 1 (5.5) | 1 (4.5) | 2 (3.7) | − | 1 (2.7) | 6 (11.8) | 11 (5.0) |
| Mean admission glucose ± | ||||||||
| SD, mmol/1 | 8.2 ± 2.2 | 7.3 ± 2.6 | 7.2 ± 1.9 | 8.1 ± 3.1 | 7.1 ± 2.4 | 7.9 ± 4.2 | 8.1 ± 2.4 | 7.7 ± 0.5 |
Data are number (%), unless otherwise indicated. The Bamford classification is the clinical classification of the IS subtype, and the TOAST classification is the mechanism of disease for IS subtypes. n = Number of patients lysed; LACS = lacunar syndrome; PACS = partial anterior circulation syndrome; TACS = total anterior circulation syndrome; POCS = posterior circulation syndrome.