Table 4.
Relationship between primary molecular cytogenetic abnormalities and specific CRAB (hypercalcemia, renal failure, anemia, bone disease) feature at diagnosis*
| FISH abnormality | Overall (n=484) | Hypercalcemia (n=59) | Renal Insufficiency (n=98) | Anemia (n=242) | Bone Disease (n=336) |
|---|---|---|---|---|---|
| Trisomy (ies) without IgH abnormality | 201 (42%) | 26 (44.1%) | 33 (33.7%) | 100 (41.3%) | 146 (43.5%) |
| IgH abnormality without trisomy (ies) | 146 (30%) | 21 (35.6%) | 44 (44.9%) | 84 (34.7%) | 95 (28.3%) |
| t(11;14) | 74 (15%) | 7 (11.9%) | 16 (16.3%) | 38 (15.7%) | 52 (15.5%) |
| t(4;14) | 28 (6%) | 7 (11.9%) | 10 (10.2%) | 18 (7.4%) | 18 (5.4%) |
| t(14;16) | 19 (4%) | 3 (5.1%) | 9 (9.2%) | 15 (6.2%) | 10 (3.0%) |
| t(14;20) | 1 (<1%) | 0 (0.0%) | 1 (1.0%) | 1 (0.4%) | 1 (0.3%) |
| Unknown partner/deletion of IgH region | 24 (5%) | 4 (6.8%) | 9 (9.2%) | 13 (5.4%) | 15 (4.5%) |
| IgH abnormality with Trisomy (ies) | 74 (15%) | 6 (10.2%) | 7 (7.1%) | 33 (13.6%) | 47 (14.0%) |
| t(11;14) | 12 (3%) | 1 (1.7%) | 1 (1.0%) | 5 (2.1%) | 7 (2.1%) |
| t(4;14) | 19 (4%) | 2 (3.4%) | 2 (2.0%) | 11 (4.5%) | 10 (3.0%) |
| t(14;16) | 5 (1%) | 0 (0.0%) | 1 (1.0%) | 4 (1.7%) | 3 (0.9%) |
| t(6;14) | 3 (<1%) | 0 (0.0%) | 1 (1.0%) | 1 (0.4%) | 2 (0.6%) |
| Unknown partner/deletion of IgH region | 35 (7%) | 3 (5.1%) | 2 (2.0%) | 12 (5.0%) | 25 (7.4%) |
| Monosomy 14 in absence of IgH translocations or trisomy (ies) | 22 (4.5%) | 2 (3.4%) | 4 (4.1%) | 9 (3.7%) | 17 (5.1%) |
| Other cytogenetic abnormalities in absence of IgH translocations or trisomy (ies) or monosomy 14* | 26 (5.5%) | 3 (5.1%) | 5 (5.1%) | 10 (4.1%) | 18 (5.4%) |
| Normal | 15 (3%) | 1 (1.7%) | 4 (4.1%) | 5 (2.1%) | 12 (3.6%) |
*
Patients may appear in multiple columns.
*
Number and proportion represents the breakdown of patients presenting with each MDE according to cytogenetic subtype