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. Author manuscript; available in PMC: 2015 Jan 7.
Published in final edited form as: Cell Metab. 2014 Jan 7;19(1):73–83. doi: 10.1016/j.cmet.2013.11.024

Figure 1. Steroidal ligands control C. elegans development and lifespan via the nuclear hormone receptor DAF-12.

Figure 1

(A) Under favorable conditions, insulin/IGF and TGF-β signaling drive biosynthesis of steroidal DAF-12-ligands. Liganded DAF-12 promotes development, in part via transcription of the let-7-family microRNA’s mir-84 and mir-241. Under unfavorable conditions, ligand biosynthesis is inhibited, resulting in interaction of unliganded DAF-12 with its co-repressor DIN-1.

(B) Previously described DAF-12-ligands and proposed biosynthetic pathways. DAF-12-ligand biosynthesis is downregulated in response to dauer pheromone, a blend of ascarosides, e.g. the shown ascr#2 (red).