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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2013 Aug 1;65:1455–1463. doi: 10.1016/j.freeradbiomed.2013.07.040

Table 2. Lung lactate and pyruvate production over the 15 min treatment periods (μmol ·15 min−1·gram−1 dry lung) in Protocol 1 studies.

Measurements were made in pulmonary venous effluent samples of a subset of lungs in Table 1. The values are means ± SE. Statistical analysis was carried out as described in Table 1. Means with the same letter designation are in the same group and not significantly different (p>0.05); means with different letter designations are in different groups and significantly different from each other (p<0.05).

Treatment n Lactate Pyruvate Lactate +
Pyruvate
Vehicle Control 4 12.36 ± 1.64 c 0.88 ± 0.11 d 13.24 ± 1.66 c
Rotenone 4 38.62 ± 3.14 a 0.87 ± 0.14 d 39.49 ± 3.12 a
Rotenone + CoQ1 3 24.64 ± 1.96 b 2.58 ± 0.20 a 27.23 ± 1.92 b
CoQ1 4 14.77 ± 2.02 c 2.12 ± 0.18 a,b 16.90 ± 2.08 c
Rotenone + CoQ1 + Dicumarol 4 34.31 ± 0.81 a 1.70 ± 0.26 b,c 36.01 ± 0.97 a
Rotenone + CoQ1 +
Antimycin A
4 34.63 ± 2.22 a 1.42 ± 0.06 c 36.05 ± 2.19 a