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Cytokine Genes Do Not Require TRIF
| Fold induction (eVLP/control) | |||
|---|---|---|---|
| Genes analyzed | TRIF+/+ DCs | TRIF−/−DCs | Significance P value (≤0.05) |
| TNFα | 13.8 | 9.6 | 0.03a |
| IL-6 | 15.1 | 14.3 | 0.06n.s. |
| IL-1β | 5.7 | 5.0 | 0.07n.s. |
| IL-12p40 | 2.8 | 4.0 | 0.04a |
P≤0.05; n.s., no significance.
BMDCs from TRIF+/+ Wt and TIRIF−/− mice were stimulated with eVLP, and mRNA expression of indicated cytokines was measured by qRT-PCR as in Fig. 3. Values represent the mean duplicate samples from 3 independent experiments±SEM.
