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ROS promote pathogen elimination by enzymatic mechanisms. After azurophile granules fuse to the phagosome in neutrophils, superoxide promotes K+ influx to compensate for negative charges. K+ promotes enzyme release from an anionic matrix (green) inside the phagosome, allowing enzymatic assault of pathogens. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
