FIG. 3.

ROS promote pathogen elimination by autophagy. NOX2-derived superoxide promotes LC3 recruitment to the autophagosome. The recognition of microbes in selective autophagy is mediated by proteins that bind to LC3 in a process called xenoautophagy. The autophagosome then fuses with lysosome, where pathogen undergoes an enzymatic assault. LC3, microtubule associated protein 1A/1B light chain 3. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars