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High levels of ROS inhibit mTOR. The nutrient sensor mTOR is kept repressed by AMPK stimulation, a process that can be reinforced by ROS production. The inhibition of mTOR can potentially reduce the viral burden by autophagy, cell death of infected reservoirs, or stimulation of CD8 cell memory. AMPK, AMP-activated kinase; mTOR, mammalian target of rapamycin.
