Table 4.
Description of the selected polymorphisms in the fatty acid desaturase (FADS) gene cluster.
| Gene | dbSNP No. 1 | Sequence 2 | Position | MAF | Genotype/Frequency | ||
|---|---|---|---|---|---|---|---|
| 11 | 12 | 22 | |||||
| FADS3 | rs174456 | CTAC[A/C]TGGC | Intron | 0.299 | A/A (n = 102) | A/C (n = 89) | C/C (n = 18) |
| 0.488 | 0.426 | 0.086 | |||||
| Intergenic FADS2-FADS3 | rs174627 | TCTG[C/T]GTAG | Intergenic | 0.124 | G/G (n = 159) | A/G (n = 48) | A/A (n = 2) |
| 0.761 | 0.230 | 0.010 | |||||
| FADS2 | rs482548 | ACAC[C/T]GTGG | 3' UTR | 0.126 | C/C (n = 161) | C/T (n = 40) | T/T (n = 6) |
| 0.778 | 0.193 | 0.029 | |||||
| FADS2 | rs2072114 | GTTC[A/G]GGTC | Intron | 0.110 | A/A (n = 167) | A/G (n = 38) | G/G (n = 4) |
| 0.799 | 0.182 | 0.019 | |||||
| Intergenic FADS1-FADS2 | rs12807005 | CATG[A/G]ATCA | Intergenic | 0.012 | G/G (n = 204) | A/G (n = 5) | A/A (n = 0) |
| 0.976 | 0.024 | 0.000 | |||||
| Intergenic FADS2-FADS3 | rs174448 | CTGA[C/T]TTCT | Intergenic | 0.363 | A/A (n = 78) | A/G (n = 109) | G/G (n = 21) |
| 0.375 | 0.524 | 0.101 | |||||
| FADS2 | rs2845573 | CTCA[C/T]GTTA | Intron | 0.081 | A/A (n = 177) | A/G (n = 30) | G/G (n = 2) |
| 0.847 | 0.144 | 0.010 | |||||
| FADS3 | rs7394871 | GGAC[A/C]CCTG | Intron | 0.072 | C/C (n = 181) | A/C (n = 26) | A/A (n = 2) |
| 0.866 | 0.124 | 0.010 | |||||
| FADS3 | rs7942717 | AACG[A/G]GTGC | Intron | 0.117 | A/A (n = 161) | A/G (n = 47) | G/G (n = 1) |
| 0.770 | 0.225 | 0.005 | |||||
| Intergenic FADS2-FADS3 | rs7482316 | TCAA[A/G]CTGC | Intergenic | 0.103 | A/A (n = 168) | A/G (n = 39) | G/G (n = 2) |
| 0.804 | 0.187 | 0.010 | |||||
| FADS2 | rs174602 | ACCC[A/G]TCCT | Intron | 0.184 | T/T (n = 141) | C/T (n = 59) | C/C (n = 9) |
| 0.675 | 0.282 | 0.043 | |||||
| FADS2 | rs498793 | TAAC[A/G]CAGG | Intron | 0.456 | C/C (n = 62) | C/T (n = 99) | T/T (n = 43) |
| 0.098 | 0.717 | 0.186 | |||||
| FADS2 | rs7935946 | GTTC[C/T]GGGA | Intron | 0.041 | C/C (n = 195) | C/T (n = 11) | T/T (n = 3) |
| 0.933 | 0.053 | 0.014 | |||||
| FADS1 | rs174546 | CTGC[C/T]TTGG | 3' UTR | 0.297 | C/C (n = 103) | C/T (n = 86) | T/T (n = 19) |
| 0.498 | 0.412 | 0.091 | |||||
| FADS2 | rs174570 | TTGA[C/T]GTAG | Intron | 0.125 | C/C (n = 159) | C/T (n = 46) | T/T (n = 3) |
| 0.764 | 0.221 | 0.014 | |||||
| FADS2 | rs174579 | CTTT[C/T]CAGG | Intron | 0.202 | C/C (n = 127) | C/T (n = 78) | T/T (n = 3) |
| 0.611 | 0.375 | 0.014 | |||||
| FADS2 | rs174611 | TGGA[C/T]CCTG | Intron | 0.258 | T/T (n = 113) | C/T (n = 84) | C/C (n = 12) |
| 0.541 | 0.402 | 0.057 | |||||
| FADS2 | rs174616 | CTCA[C/T]GTTC | Intron | 0.498 | A/A (n = 51) | A/G (n = 108) | G/G (n = 50) |
| 0.244 | 0.517 | 0.239 | |||||
| FADS2 | rs968567 | CCGG[A/G]AGCT | 5' UTR | 0.160 | G/G (n = 144) | A/G (n = 63) | A/A (n = 2) |
| 0.689 | 0.301 | 0.010 | |||||
1 dbSNP No. from HapMap Data Rel 28 Phase II + III, August 10 on NCBI b36 Assembly dbSNP b126 database; 2 Genes sequences from dbSNP short genetics variations NCBI reference assembly.