Table 1.

Published in vivo usage of RNA interference as a therapeutic tool in Nontraumatic Brain Hemorrhage Models.

Reference	Targeted Protein	Pathophysiological Pathway Targeted	Injury Model	Delivery Method	Delivery Timepoint	Result
[12]	CHOP	apoptosis	Endovascular perforation of MCA	ICV	24 h prior	↓ edema ↓ BBB disruption ↓ behavior deficit
[13]	CHOP	apoptosis	Endovascular perforation of MCA	ICV	24 h prior	↓ cell death Reversed detrimental phenotypic changes of the blood vessels
[14]	PUMA	apoptosis	Endovascular perforation	ICV	Immediately after	↓ cell death ↓ edema ↓ behavior deficit ↓ BBB disruption ↓ mortality rate
[15]	VAP-1	neuroinflammation	Collagenase Injection	ICV	48 h prior	↓ edema ↑ behavior ↓ microglial activation ↓ proinflammatory molecule secretion