Table 3.
Published in vivo usage of RNA interference as a therapeutic tool in traumatic brain injury models.
| Reference | Targeted Protein | Pathophysiological Pathway Targeted | Injury Model | Delivery Method | Delivery Timepoint | Result |
|---|---|---|---|---|---|---|
| [51] | Claudin-5 | Edema | Cold Induced Mice | Tail Vein Injection | <1 h Post | ↓ lesion size ↑ cognitive outcome |
| [49] | Int6 | Angiogenesis | Cold Induced Rats | Internal carotid Artery | 1 h Post | ↓ lesion |
| [55] | Fzd2 | Ca2+ Accumulation | Weight Drop Rats | Direct Hippocampal Injection | 48 h Prior | ↓ Fzd2, Wnt5a, p-CaMKII ↓ intracellular Ca2+ |
| [54] | AQP4 | Edema Formation | Controlled Cortical Injury | Intracortical Injection | Immediately after injury and 2 d after injury (2 injections) | Acutely, ↑ motor function ↑ neuronal survival ↓ BBB disruption ↓ edema Chronically, ↑ memory ↑ neuronal survival |