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. 2011 Feb 18;2(1):191–209. doi: 10.3390/genes2010191

Figure 5.

Figure 5

Sequence divergence of the red- and green-opsin genes in human and macaque. The graph shows the divergence between the human red-opsin (long-wave: LW) and green-opsin (medium-wave: MW) genes of intron 4, exon 5, and intron 6. The divergence data was taken from [46]. The gene structure of the region is shown below with the introns 4 and 6 represented by black lines and the exon 5 represented by a gray box. Regions where the similarity is higher between paralogs of the same species than between orthologs of other species (i.e., the introns) due to frequent gene conversion is in a light red background, whereas regions where the similarity is higher between the orthologs than the paralogs (i.e., the exon) are in a light blue background. The two blue arrows indicate the positions of the two fixed amino acid substitutions that are largely responsible for the difference in color sensitivity [53]. The amino acid sequences of the red-opsin (LW) and green-opsin (MW) genes of human and macaque [49] around the two functionally significant substitutions are shown below. The sites in blue are sites where the difference is fixed between either of the orthologous pair, and the sites of the two functionally significant substitutions are in bold.