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Possible crosstalk between S-nitrosylation and S-glutathionylation targeting different cysteine residues. (A) Modification of one cysteine by S-glutathionylation affects the local environment for a second cysteine, thus modulating the reactivity of the second cysteine residue to S-nitrosylation. (B) The modification of one cysteine by S-glutathionylation has an allosteric effect on another cysteine residue at a different place, modulating its reactivity to S-nitrosylation.
