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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Affect Disord. 2013 Nov 16;155:247–254. doi: 10.1016/j.jad.2013.08.041

Figure 3.

Figure 3

The exploratory profile of DAT KD and WT mice on a C57BL/6J background tested in the BPM a third time, 10 days after their second testing. The profile of mice was assessed in the BPM for a prolonged period of 3-h and divided in three 60-min time bins. Although both WT and KD mice habituated over time, KD mice remained hyperactive throughout the 3-h period as measured by increased transitions (a) and more center entries (b). While WT mice decreased rearing over time, KD mice did not and exhibited increased rearing at each time bin (c). WT mice did not change in holepoking behavior over time, while KD mice exhibited increased holepoking behavior compared to WT mice and over time (d). Although both WT and KD mice exhibited increased spatial d and reduced entropy over time, KD mice moved in straighter paths (e) and exhibited disordered movement organization (f) compared to WT mice throughout the 3-h period. Data are presented as mean ± S.E.M. *p<0.05 when compared to WT mice.