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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Hepatol. 2013 Feb 21;59(1):131–137. doi: 10.1016/j.jhep.2013.02.007

Table 2.

Liver histology from 50 patients with baseline biopsies

    Portal Areas (mean, range) 14.3 (5–46)

      Steatosis Grade (mean) 1.7

0 (<5% of hepatocytes) 5 (10)1
1 (5–33% of hepatocytes) 19 (38)
2 (33–67% of hepatocytes) 13 (26)
3 (>67% of hepatocytes) 13 (26)

      Microvesicular Steatosis 5 (10)

  Lobular Inflammation Grade (mean) 1.3

0 (no foci) 2 (4)
1 (<2 foci/20x hpf) 34 (68)
2 (2–4 foci/20x hpf) 9 (18)
3 (>4 foci/20x hpf) 5 (10)

    Portal Inflammation (mean score) 1

0 (None) 7 (14)
1 (Mild) 34 (68)
2 (More than mild) 9 (18)

    Ballooning Injury (mean score) 1.1

0 (None) 13 (26)
1 (Few) 17 (34)
2 (Many) 20 (40)

        Acidophil Bodies 18 (37)

      Megamitochondria 7 (14)

        Mallory Bodies 6 (12)

    Fibrosis (mean stage) 2.1

0 (None) 7 (14)
1A (Mild perisinusoidal only) 6 (12)
1B (Moderate perisinuosoidal) 3 (6)
1C (Periportal only) 3 (6)
2 (Periportal and perisinusoidal) 10 (20)
3 (Bridging fibrosis) 13 (26)
4 (Cirrhosis) 8 (16)

  NAFLD Activity Score (mean) 4.2

Diagnostic Classification

Not Steatohepatitis 9 (18)
Borderline Steatohepatitis 10 (20)2
Definite Steatohepatitis 31 (62)

hpf, High Power Field.

1

Data are presented as N (%) unless otherwise indicated.

2

One pediatric patient had a borderline zone 1 pattern.

HHS Vulnerability Disclosure