Table 2.
Liver histology from 50 patients with baseline biopsies
| Portal Areas (mean, range) | 14.3 (5–46) |
|---|---|
| Steatosis Grade (mean) | 1.7 |
| 0 (<5% of hepatocytes) | 5 (10)1 |
| 1 (5–33% of hepatocytes) | 19 (38) |
| 2 (33–67% of hepatocytes) | 13 (26) |
| 3 (>67% of hepatocytes) | 13 (26) |
| Microvesicular Steatosis | 5 (10) |
| Lobular Inflammation Grade (mean) | 1.3 |
| 0 (no foci) | 2 (4) |
| 1 (<2 foci/20x hpf) | 34 (68) |
| 2 (2–4 foci/20x hpf) | 9 (18) |
| 3 (>4 foci/20x hpf) | 5 (10) |
| Portal Inflammation (mean score) | 1 |
| 0 (None) | 7 (14) |
| 1 (Mild) | 34 (68) |
| 2 (More than mild) | 9 (18) |
| Ballooning Injury (mean score) | 1.1 |
| 0 (None) | 13 (26) |
| 1 (Few) | 17 (34) |
| 2 (Many) | 20 (40) |
| Acidophil Bodies | 18 (37) |
| Megamitochondria | 7 (14) |
| Mallory Bodies | 6 (12) |
| Fibrosis (mean stage) | 2.1 |
| 0 (None) | 7 (14) |
| 1A (Mild perisinusoidal only) | 6 (12) |
| 1B (Moderate perisinuosoidal) | 3 (6) |
| 1C (Periportal only) | 3 (6) |
| 2 (Periportal and perisinusoidal) | 10 (20) |
| 3 (Bridging fibrosis) | 13 (26) |
| 4 (Cirrhosis) | 8 (16) |
| NAFLD Activity Score (mean) | 4.2 |
| Diagnostic Classification | |
| Not Steatohepatitis | 9 (18) |
| Borderline Steatohepatitis | 10 (20)2 |
| Definite Steatohepatitis | 31 (62) |
hpf, High Power Field.
1
Data are presented as N (%) unless otherwise indicated.
2
One pediatric patient had a borderline zone 1 pattern.