Table 2.
Liver histology from 50 patients with baseline biopsies
Portal Areas (mean, range) | 14.3 (5–46) |
---|---|
Steatosis Grade (mean) | 1.7 |
0 (<5% of hepatocytes) | 5 (10)1 |
1 (5–33% of hepatocytes) | 19 (38) |
2 (33–67% of hepatocytes) | 13 (26) |
3 (>67% of hepatocytes) | 13 (26) |
Microvesicular Steatosis | 5 (10) |
Lobular Inflammation Grade (mean) | 1.3 |
0 (no foci) | 2 (4) |
1 (<2 foci/20x hpf) | 34 (68) |
2 (2–4 foci/20x hpf) | 9 (18) |
3 (>4 foci/20x hpf) | 5 (10) |
Portal Inflammation (mean score) | 1 |
0 (None) | 7 (14) |
1 (Mild) | 34 (68) |
2 (More than mild) | 9 (18) |
Ballooning Injury (mean score) | 1.1 |
0 (None) | 13 (26) |
1 (Few) | 17 (34) |
2 (Many) | 20 (40) |
Acidophil Bodies | 18 (37) |
Megamitochondria | 7 (14) |
Mallory Bodies | 6 (12) |
Fibrosis (mean stage) | 2.1 |
0 (None) | 7 (14) |
1A (Mild perisinusoidal only) | 6 (12) |
1B (Moderate perisinuosoidal) | 3 (6) |
1C (Periportal only) | 3 (6) |
2 (Periportal and perisinusoidal) | 10 (20) |
3 (Bridging fibrosis) | 13 (26) |
4 (Cirrhosis) | 8 (16) |
NAFLD Activity Score (mean) | 4.2 |
Diagnostic Classification | |
Not Steatohepatitis | 9 (18) |
Borderline Steatohepatitis | 10 (20)2 |
Definite Steatohepatitis | 31 (62) |
hpf, High Power Field.
Data are presented as N (%) unless otherwise indicated.
One pediatric patient had a borderline zone 1 pattern.