Table 4.
Comparison of liver histology at baseline and on metreleptin.
| Baseline N=27 |
On Leptin N=27 |
p value1 | |
|---|---|---|---|
| Steatosis Grade (mean) | 1.8 | 0.9 | 0.0004 |
| 0 (<5% of hepatocytes) | 2 (7) | 12 (44) | |
| 1 (5–33% of hepatocytes) | 10 (37) | 9 (33) | |
| 2 (33–67% of hepatocytes) | 7 (26) | 4 (15) | |
| 3 (>67% of hepatocytes) | 8 (30) | 2 (7) | |
| Lobular Inflammation Grade (mean) | 1.3 | 1.1 | 0.097 |
| 0 (no foci) | 1 (4) | 3 (11) | |
| 1 (<2 foci/20x hpf) | 19 (70) | 18 (67) | |
| 2 (2–4 foci/20x hpf) | 4 (15) | 5 (19) | |
| 3 (>4 foci/20x hpf) | 3 (11) | 1 (4) | |
| Portal Inflammation (mean score) | 1.1 | 0.9 | 0.13 |
| 0 (None) | 3 (11) | 7 (26) | |
| 1 (Mild) | 18 (67) | 15 (56) | |
| 2 (More than mild) | 6 (22) | 5 (19) | |
| Ballooning Injury (mean score) | 1.2 | 0.4 | 0.0002 |
| 0 (None) | 5 (19) | 18 (67) | |
| 1 (Few) | 11 (41) | 6 (22) | |
| 2 (Many) | 11 (41) | 3 (11) | |
| Fibrosis (mean stage) | 1.9 | 1.9 | 1 |
| NAFLD Activity Score (mean) | 4.3 | 2.4 | <0.0001 |
| Diagnostic Classification | |||
| Not Steatohepatitis | 4 (15) | 18 (67) | 0.0003 |
| Borderline Steatohepatitis | 5 (19)1 | 3 (11)2 | |
| Definite Steatohepatitis | 18 (67) | 6 (22) | |
hpf, High Power Field.
1
Paired t-test for continuous variables; Wilcoxon for ordered nominal variables.
2
One pediatric patient had a borderline zone 1 pattern.