Table 2. Viremia and mortality in the black-faced langur after infection with TC-adapted KFDV.
* Positive logarithms of adult mouse LD50 titers/0.03 ml.
| Passage | Dose*/Route | Monkey Number | LD50 Titer*
Day post-inoculation |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |||
| MK138 | 5.9/IV | 147 | 1.5 | 2.5 | 3.6 | 2.0 | 2.4 | 1.6 | 1.0 | N | N | |
| MK138 | 5.9/IV | 171 | 1.7 | 2.6 | 1.6 | 1.2 | 0.7 | 0.2 | N | T | N | |
| MK138 | 5.9/IV | 207 | 1.1 | 0.4 | T | T | T | N | N | N | N | |
| MK138 | 5.9/IV | 220 | 0.5 | 0.4 | 0.6 | T | 0 | N | T | N | N | |
| MK138 | 5.9/IV | 222 | 1.6 | 0.8 | 0.9 | N | T | N | N | N | N | |
| MK138 | 5.9/IV | 225 | 0.5 | 3.1 | 3.2 | 4.3 | X | |||||
| MK177 | 3.9/SC | 22 | N | 2.0 | 3.1 | 4.2 | 4.4 | 3.5 | 3.2 | 2.7 | T | T |
| MK177 | 2.9/SC | 23 | N | T | 3.0 | 3.8 | 4.0 | 3.3 | 3.5 | <2.0 | T | N |
| MK177 | 1.9/C | 33 | N | T | <2.0 | 4.0 | 5.0 | 5.7 | 4.7 | <3.0 | <2.0 | T |
| MK177 | 8.3/SC | 30 | T | 3.3 | 4.5 | 3.3 | T | T | N | N | N | N |
| MK177 | 8.3/SC | 85 | ≥2.0 | ≥4.0 | 5.5 | 6.0 | 6.3 | 5.1 | 4.1 | 4.0 | ≥2.0 | TX |
| MK177 | 4.0/SC | 101 | T | T | ≥3.5 | 4.3 | 5.1 | 3.7 | 3.5 | 3.2 | ≥2.0 | T |
| Plaque | 7.9/SC | 87 | 1.9 | ≥3.5 | 4.5 | 3.3 | T | T | N | N | N | N |
| Plaque | 7.9/SC | 92 | 1.9 | ≥3.1 | 4.5 | 4.0 | 4.1 | 3.0 | N | N | N | N |
| Plaque | 3.9/SC | 100 | T | ≥2.0 | ≥3.3 | 5.0 | 4.0 | 3.6 | 2.5 | N | N | N |
| Plaque | 3.9/SC | 102 | N | ≥2.0 | 3.5 | 3.7 | 4.3 | 4.1 | 3.2 | 3.0 | T | N |
| CE41 | 5.7/SC | 193 | T | ≥3.5 | 4.0 | 4.8 | 5.0 | 4.0 | 3.8 | T | 4.0 | T |
| CE41 | 5.7/SC | 194 | 2.7 | ≥5.5 | 5.5 | 5.7 | 5.7 | 4.5 | 5.7 | ≥2.0 | N | T |
| CE41 | 5.7/SC | 197 | T | 2.3 | 3.7 | 3.4 | 3.5 | T | T | N | N | N |
| CE41 | 5.7/SC | 198 | T | T | 3.7 | 5.3 | 5.0 | 4.5 | 5.0 | T | T | N |
Peak titer is underlined.
T = Trace; N = Negative; X = Died; IV = Intravenous; SC = Subcutaneous.