Skip to main content
. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Cell Mol Bioeng. 2013 Sep;6(3):279–286. doi: 10.1007/s12195-013-0289-4

Figure 4. Schematic model for the SB203580-mediated relief of adaptation to stretching investigated in this manuscript.

Figure 4

Cyclic stretch conditioning activates cellular mechanotransduction pathways, including ERK and p38 MAPK. Activated p38 exerts an inhibitory effect on ERK, thereby limiting downstream proliferation and synthesis of type I collagen. With application of the p38 inhibitor SB203580, stretching-induced ERK signaling is enhanced, as are proliferation and downstream collagen production (bold).