Figure 2.

Effects of ADN-1184 in tests related to antipsychotic-like activity. (A) Effects of ADN-1184 on hyperlocomotor activity induced by MK-801 (0.3 mg·kg⁻¹). Each symbol represents mean ± SEM of the distance travelled by rats in the 16–45 min period after MK-801 administration (n = 8 per group). Drug or vehicle was administered 45 min before MK-801. *P < 0.05, **P < 0.01, compared with MK-801-treated group using Newman–Keuls post hoc test, following significant anova. Baseline activity is shown by the dotted line. (B) Effects of ADN-1184 on stereotypies induced by MK-801 (1.2 mg·kg⁻¹). Each symbol represents mean ± SEM of the duration of stereotyped behaviour in the 11–15 min period after MK-801 administration (n = 8 per group). *P < 0.05, **P < 0.01, compared with vehicle-treated group using Mann–Whitney U-test, following significant Kruskal–Wallis anova. (C) Effects of ADN-1184 on conditioned avoidance. Each symbol represents mean ± SEM number of CAR recorded during a session with 30 trials, 60 min after drug administration (n = 7 per group). *P < 0.05, **P < 0.01, CAR compared with vehicle-treated group using Newman–Keuls post hoc test, following significant anova.