Figure 3.

Effects of ADN-1184 in tests related to antidepressant-like activity and impairment of memory. (A) Effects of ADN-1184 on forced swimming test. Each symbol represents mean ± SEM immobility time during 5 min forced swimming session. Drug or vehicle was administered 1 h before the test (n = 16 for vehicle group, n = 8 per drug group). **P < 0.01, compared with vehicle-injected control group using Newman–Keuls post hoc test, following significant anova. (B) Effects of ADN-1184 on step-through latency performed 1 day after training. Animals were given drug or vehicle 1 h before training session. Each symbol represents mean ± SEM latency to enter the dark compartment (n = 8 per group). **P < 0.01, compared with vehicle group using Mann–Whitney U-test, following significant results of Kruskal–Wallis anova.