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. 2014 Jan 24;171(4):1007–1018. doi: 10.1111/bph.12520

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Copyright © 2013 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Differences between currents induced by 5-HT and pCA respectively. Xenopus laevis oocytes expressing hSERT were clamped to −60 mV. Currents induced by 3 μM 5-HT were compared with currents from the same cell induced by 3 μM pCA. (A) 3 μM 5-HT was applied to the cell for 10 s and subsequently washed away with a gravity driven perfusion system. (B) The same procedure was repeated with 3 μM pCA. (C) The current decays were fitted to mono-exponential functions and the time constants were plotted in the bar graph. A comparison of the decay time constants following 5-HT (5.8 s ± 1.3 s, n = 6) and pCA removal (23.3 s ± 4 s, n = 6) revealed a significantly slower time constant for pCA (*** = P < 0.001, Mann–Whitney U-test).