Table 4.
Binding rate constants of AEDs for the NaV1.1, NaV1.2, NaV1.3 and NaV1.6 α-subunits
| Binding rate constant (× 103 M−1 s−1) | |||
|---|---|---|---|
| Subunits | Phenytoin | Carbamazepine | Lamotrigine |
| NaV1.1 | 14.2 ± 2.0** (27) | 31.7 ± 2.3a (25) | 15.4 ± 0.8**;aa,bb,cc1999 (18) |
| NaV1.2 | 8.0 ± 1.2** (18) | 28.8 ± 3.6 (33) | 9.2 ± 1.0**;aa (30) |
| NaV1.3 | 10.5 ± 1.2** (29) | 26.1 ± 1.4 (14) | 9.3 ± 0.3**;bb (17) |
| NaV1.6 | 8.5 ± 1.9** (23) | 23.3 ± 0.9a (24) | 8.4 ± 0.1**;cc (30) |
Sample sizes are indicated in brackets.
a
P < 0.05.
aa bb cc
P < 0.01, comparison between subunits.
**
P < 0.01, comparison with carbamazepine (test for homogeneity of regression coefficients).