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. 2014 Feb 14;9(2):e87915. doi: 10.1371/journal.pone.0087915

Figure 11. TLR4 antagonist naltrexone blocks ethanol neuroimmune activation.

Figure 11

A: Ethanol (100 mM, 4 days) induction of proinflammatory signaling molecules were significantly blocked by TLR4 antagonist naltrexone (minor form, 250 fM). Shown are mean ± SEM of mRNA levels relative to control (*p<0.001 compared with Control; #p<0.01 compared with Ethanol; n = 3). B: Ethanol induction of TNFα and IL-1β mRNA is completely blocked by naltrexone (plus form, 250 pM) (*p<0.001 compared to Control; #p<0.0001 compared with EtOH; n = 3).