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. 2014 Feb 14;9(2):e87743. doi: 10.1371/journal.pone.0087743

Table 6. Summary of study outcomes – Iron Treatment vs. Malaria Risk.

Author, Year Study Design Outcome Exposure% (n) Comparison to exposure% (n) Risk estimate (95% CI)or p-value
Oppenheimer, 1986 [63] Retrospective Cohort Postnatal malaria- primigravida Total Dose Iron Infusion 20·4% (11/54) No Total Dose Iron Infusion 4·5% (3/67) RR 4·55 (1·34–15·49) OR 5·46 (1·44, 20·7)
Postnatal malaria- multigravida Total Dose Iron Infusion 8·4% (8/95) No Total Dose Iron Infusion 7·6% (14/184) RR 1·11 (0·48–2·54) OR 1·12 (0·45, 2·76)
Byles, 1970 [62] Prospective Cohort Generalized reactions after total dose iron infusion Total dose iron+Concurrent CQ 1·5% (7/462) Total dose iron+No concurrent CQ 8·6% (39/455) OR 0·16 (0·07–0·37) RR 0·18 (0·08–0·39)
PF parasitemia present among participants with generalized reactions after total dose iron infusion Total dose iron+Concurrent CQ 0·0% (0/7) Total dose iron+No concurrent CQ 28·2% (11/39) p = 0·17

CI: confidence interval. CQ: chloroquine. OR: odds ratio. PF: Plasmodium falciparum. RR: risk ratio.